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| NAME | GENDER | ORIGIN | MEANING |
| Sabra |  | Hebrew | Cactus Plant |
| Sabrina | | English | Goddess of Severn River |
| Sacha | | Greek | Helper of Mankind |
| Sachi | | Japanese | Girl Child |
| Sadie | | Hebrew | Princess |
| Salena | | Latin | Salt |
| Salisbury |  | Anglo Saxon | Dry Town |
| Sally | | Hebrew | Princess |
| Salome | | Hebrew | Asked of God |
| Samantha | | Hebrew | Listener |
| Samara | | Hebrew | Watch or Outlook |
| Samson | | Hebrew | Bright as the Sun |
| Samuel | | Hebrew | Answer to Prayers |
| Samuela | | Hebrew | Asked of God |
| Sanborn | | Old English | Residence Name |
| Sanders | | Greek | Helper of Mankind |
| Sandra | | Greek | Helper of Mankind |
| Sanford | | Old English | From the Sandy Ford |
| Santos | | Spanish | Of the Saints |
| Sapphire | | Hebrew | Precious Gem |
| Sarah | | Hebrew | True Princess |
| Sargent | | Old French-Latin | Occupation Name |
| Sarita | | Variant of Sarah | Little Princess |
| Saul | | Hebrew | Longed For |
| Sawyer | | Middle English | Wood Cutter |
| Schuyler | | Dutch | A Shelter |
| Scott | | Old English | From Scotland |
| Sean | | Irish Gaelic | Form of John, God's gracious gift |
| Sebastian | | Greek | Majestic |
| Sela | | Hebrew | A Rock |
| Selby | | Teutonic | Residence Name |
| Selene | | Greek | The Moon |
| Selima | | Hebrew | Peaceful |
| Selma | | Arabic | Secure |
| Septima | | Latin | The Seventh |
| Seraphine | | Hebrew | Burning or Ardent |
| Serena | | Latin | Serene |
| Serle | | Teutonic | Armed |
| Seth | | Hebrew | Appointed One |
| Seymour | | French-Latin | Moorish Saint |
| Shamus | | Irish | Form of James |
| Shana | | Hebrew | Beautiful |
| Shannon | | Gaelic | Wise |
| Sharon | | Hebrew | Plains |
| Shaw | | Old English | Residence Name |
| Sheba | | Arabic | Biblical Queen |
| Sheila | | Irish | Divine Place |
| Shelby | | Anglo Saxon | Residence Name |
| Sheldon | | Anglo Saxon | Residence Name |
| Sherard | | Anglo Saxon | Of Splendid Valor |
| Sheridan | | Celtic | The Wild Man |
| Sherlock | | Old English | Fair-Haired |
| Sherman | | Old English | Occupation Name |
| Sherwin | | Anglo Saxon | Eminent in Friendship |
| Sherwood | | Old English | From the Bright Forest |
| Shiloh | | Hebrew | God Is Great, Peaceful One, Messiah |
| Shirley | | Old English | From the White Meadow |
| Sibley | | Anglo Saxon | Related or Family |
| Sibyl | | Greek | Wise or Prophetic |
| Sidra | | Latin | Starlike |
| Sigmund | | Teutonic | Victorious Protection |
| Silas | | Latin | Man of the Forest |
| Silver | | Anglo Saxon | White |
| Silvester | | Latin | Forest Dweller |
| Simon | | Hebrew | He who has Heard |
| Simona | | Hebrew | Heard |
| Sinclair | | Latin | The Illustrious |
| Sinead | | Irish | God is Gracious |
| Siobhan | | Irish | Form of Jane and Judith, God is Gracious |
| Sirena | | Greek | A Siren |
| Sloane | | Celtic | Warrior |
| Sol | | Latin | The Sun |
| Solomon | | Hebrew | Peaceful |
| Spencer | | English | Steward |
| Standish | | Old English | Residence Name |
| Stanford | | Old English | Residence Name |
| Stanislaus | | Slavonic | Glory of the Camp |
| Stanley | | English | Stony Field |
| Stanway | | Old English | Residence Name |
| Stedman | | Anglo Saxon | Residence Name |
| Stephen | | Greek | Crown |
| Sterling | | English | High Quality |
| Stewart | | Anglo Saxon | A Steward |
| Sumner | | Old French-Latin | A Summoner |
| Suri | | Persian | Red Rose |
| Sutton | | Old English | Residence Name |
| Swain | | Teutonic | Youthful |
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